Herman S Overkleeft Selected Research

cyclophellitol

1/2019	Functionalized Cyclophellitols Are Selective Glucocerebrosidase Inhibitors and Induce a Bona Fide Neuropathic Gaucher Model in Zebrafish.
5/2016	Detection of Active Mammalian GH31 α-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes.

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Herman S Overkleeft Research Topics

Disease

26	Neoplasms (Cancer) 01/2021 - 06/2007
23	Gaucher Disease (Gaucher's Disease) 11/2021 - 02/2007
12	Multiple Myeloma 01/2022 - 05/2011
9	Fabry Disease (Fabry's Disease) 01/2018 - 06/2011
5	Type 2 Diabetes Mellitus (MODY) 10/2021 - 01/2009
5	Inflammation (Inflammations) 01/2021 - 01/2012
4	Mantle-Cell Lymphoma (Lymphoma, Mantle Cell) 12/2019 - 01/2012
3	Hematologic Neoplasms (Hematological Malignancy) 01/2022 - 12/2014
3	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2018 - 04/2015
3	Obesity 12/2015 - 08/2014
2	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2022 - 10/2021
2	Neuroblastoma 01/2022 - 08/2015
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2022 - 01/2019
2	Melanoma (Melanoma, Malignant) 01/2021 - 01/2019
2	Infections 01/2020 - 04/2007
2	Inborn Genetic Diseases (Disease, Hereditary) 12/2019 - 09/2016
2	Parkinson Disease (Parkinson's Disease) 01/2019 - 12/2018
2	Colitis 12/2018 - 01/2018
2	Autoimmune Diseases (Autoimmune Disease) 12/2018 - 12/2016
2	Globoid Cell Leukodystrophy (Krabbe Disease) 01/2017 - 02/2016
2	Alzheimer Disease (Alzheimer's Disease) 12/2016 - 12/2014
2	Pneumonia (Pneumonitis) 10/2015 - 03/2011
2	Insulin Resistance 01/2012 - 01/2010
2	Pathologic Processes 01/2009 - 02/2007
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 01/2022
1	Plasma Cell Leukemia 01/2022
1	Transfusion Reaction 12/2021
1	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 10/2021
1	Rheumatoid Arthritis 02/2021
1	Poisoning 01/2021
1	Ovarian Neoplasms (Ovarian Cancer) 10/2020

Drug/Important Bio-Agent (IBA)

13	Proteasome InhibitorsIBA 01/2022 - 01/2012
12	Glucosylceramidase (Glucocerebrosidase)IBA 11/2021 - 12/2010
9	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2022 - 04/2014
8	EnzymesIBA 10/2021 - 12/2015
7	Proteins (Proteins, Gene)FDA Link 01/2020 - 02/2008
7	GlycosphingolipidsIBA 12/2019 - 02/2007
6	Pharmaceutical PreparationsIBA 01/2021 - 02/2011
6	GlucosidasesIBA 01/2021 - 01/2016
5	Bortezomib (Velcade)FDA Link 10/2021 - 05/2011
5	LipidsIBA 01/2021 - 01/2014
4	AntigensIBA 02/2021 - 04/2007
4	Peptides (Polypeptides)IBA 01/2021 - 06/2007
4	LigandsIBA 01/2021 - 06/2015
4	sphingosyl beta-glucosideIBA 11/2019 - 04/2015
4	Glucosylceramides (Glucocerebrosides)IBA 11/2019 - 04/2015
4	GalactosidasesIBA 01/2018 - 08/2014
4	ceramide glucosyltransferaseIBA 03/2016 - 02/2007
4	Peptide Hydrolases (Proteases)FDA Link 10/2015 - 05/2003
3	Glucose (Dextrose)FDA LinkGeneric 10/2021 - 01/2016
3	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2021 - 01/2020
3	AnthracyclinesIBA 01/2021 - 01/2020
3	Polysaccharides (Glycans)IBA 01/2020 - 03/2011
3	ProgranulinsIBA 01/2019 - 09/2016
3	carfilzomibIBA 10/2018 - 05/2011
2	ixazomibIBA 10/2021 - 10/2018
2	Synthetic Vaccines (Recombinant Vaccines)IBA 01/2021 - 03/2017
2	Conjugate VaccinesIBA 10/2020 - 01/2019
2	Oxidoreductases (Dehydrogenase)IBA 01/2020 - 12/2019
2	Biological ProductsIBA 01/2020 - 01/2006
2	AcidsIBA 01/2020 - 05/2016
2	Glycoside Hydrolases (Endoglycosidases)IBA 12/2019 - 11/2014
2	cyclophellitolIBA 01/2019 - 05/2016
2	HydrolasesIBA 01/2019 - 08/2014
2	VaccinesIBA 01/2019 - 03/2017
2	CeramidesIBA 12/2018 - 01/2016
2	EndocannabinoidsIBA 01/2018 - 04/2015
2	Psychosine (Galactosylsphingosine)IBA 01/2017 - 02/2016
2	miglustat (Zavesca)FDA Link 03/2016 - 02/2007
2	GlycolipidsIBA 12/2015 - 05/2005
2	Matrix Metalloproteinases (MMPs)IBA 10/2015 - 01/2015
2	TrypsinIBA 04/2014 - 02/2013
2	Biomarkers (Surrogate Marker)IBA 03/2013 - 06/2011
1	wobeIBA 01/2022
1	Starch (Cornstarch)IBA 10/2021
1	Amylases FDA Link 10/2021
1	VinculinIBA 02/2021
1	OvalbuminIBA 02/2021
1	HIV Protease InhibitorsIBA 01/2021
1	ChromatinIBA 01/2021
1	Histones (Histone)IBA 01/2021
1	CytokinesIBA 01/2021
1	T-Lymphocyte Epitopes (Epitopes, T Lymphocyte)IBA 01/2021
1	Acyl-ButyrolactonesIBA 01/2021
1	major vault proteinIBA 01/2021
1	Membrane LipidsIBA 01/2021
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2021
1	Nelfinavir (Viracept)FDA Link 01/2021
1	homoserine lactoneIBA 01/2021
1	DNA (Deoxyribonucleic Acid)IBA 01/2021
1	AclarubicinIBA 11/2020
1	Cisplatin (Platino)FDA LinkGeneric 10/2020
1	PlatinumIBA 10/2020
1	Antineoplastic Agents (Antineoplastics)IBA 10/2020
1	olaparibIBA 01/2020
1	CathepsinsIBA 01/2020

Therapy/Procedure

11	Therapeutics 01/2021 - 08/2014
2	Immunotherapy 01/2021 - 04/2007
2	Enzyme Replacement Therapy 03/2016 - 03/2013
1	Drug Therapy (Chemotherapy) 01/2021